An infusion pump is a generic pump (syringe, peristaltic among others) that delivers fluids in a medical context; usually the nutrients, drugs are controlled through these devices. The rate of the infusion pump needs to be programmed by software. The programmed infusion pumps like the Chemyx syringe pump systems are better instruments to deliver small doses to the controlled patient, and they can be used for research purposes in medical science. One key point on these devices is the rates and the feeding intervals which should be programmed carefully. They can deliver nutrients or medications, such as insulin or other hormones, antibiotics, chemotherapy drugs, and pain relievers. In the following lines you will find some research cases and also additional information of syringe pump importance; the drawbacks and situations that the FDA regulates in the case of controlled patients.
A case of study with induced hyperoxia
Infusion pumps are used for studies with arterial chemoreceptors, a recent study in this field employs sedated rats to induce hyperoxia by continuous infusion of low levels of H2S. A Fusion 100 syringe pump infuse via a catheter in femoral vein at a rate of 0.30 to 0.50 ml/min (7.0 ± 1.0 μmol/min). The study shows that the acute exposure to 100% O2 decreased minute ventilation from 301 ± 51 to 210 ± 43 ml/min within 15 seconds in control conditions. However, no other significant sign was observed with H2S induced apnea. The hyperoxic tests showed that the ventilator depression provoked by high O2 is limited to the tonic background peripheral chemosensory drive to breathe, and has no impact on the carotid body stimulation produced by low levels of H2S (Philippe Haouzi, Sonobe Takashi, 2014).
Cases of study; real-time feedback-based system for infusion
Schock-Kusch et al. developed a real-time feedback-based system for optimal regulation and monitoring of a constant infusion clearance technique. At that time they programmed the Fusion 100 syringe pump with software a used a fluorescent renal marker which is called fluorescein isothiocyanate-sinistrin, they infuse the solution via a catheter into the femoral vein of rats. The constant infusion clearance allows monitoring of changes in marker concentration in vivo and in real-time; in this case, permits the optimization of the maintenance dose and individually optimized the regulation of the maintenance dose independently of glomerular filtration rate level (Schock-Kusch et al., 2012).
The importance of infusion pumps
The Chemyx Fusion 100 is an infusion pump for research purposes and differs from the infusion pumps used in a real controlled patient. These infusion devices are equipped with alarms and alerts that will activate in case of failure. Additionally, these pumps are thoroughly regulated by the FDA which received approximately 56,000 reports of adverse events associated with the operation of infusion pumps, the problems found by the FDA. These issues can compromise the safe use of external infusion pumps and lead to over-or under-infusion missed treatments, or delayed therapy. The typical problems reported for these pumps are software defects, user interface issues, mechanical and electrical failures. For that reason, the FDA proactively facilitates device improvements (FDA, infusion pumps 2018).
Concluding remarks
On this website, Chemyx offers you the best solution regarding infusion for research; the Chemyx Fusion 100 is a robust and reliable pump use with rats and with high performance in scientific studies. The above descriptions for medical research proving the advantages of Chemyx syringe pump systems. You may also find more information regarding other research subjects related to infusion pumps as the application of syringe pumps in biochemistry, biotechnology, and microfluidic studies. Please visit the different documentation that Chemyx has for you and your field of study.
References
- Philippe Haouzi, Sonobe Takashi, C.B., 2014. Oxygen-related chemoreceptor drives to breathe during H2 S infusion. Respir Physiol Neurobiol 15, 24–30. https://doi.org/10.1016/j.resp.2014.05.012.Oxygen
- Schock-Kusch, D., Shulhevich, Y., Xie, Q., Hesser, J., Stsepankou, D., Neudecker, S., Friedemann, J., Koenig, S., Heinrich, R., Hoecklin, F., Pill, J., Gretz, N., 2012. Online feedback-controlled renal constant infusion clearances in rats. Kidney Int. 82, 314–320. https://doi.org/10.1038/ki.2012.117
- https://www.fda.gov/medicaldevices/productsandmedicalprocedures/generalhospitaldevicesandsupplies/infusionpumps/